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首页- Products - GPCR/G Protein - CGRP Receptor - Calcitonin（salmon） Acetate(47931-85-1(free base))

Calcitonin（salmon） Acetate(47931-85-1(free base))

CAS No. ——

Calcitonin（salmon） Acetate(47931-85-1(free base)) ( Salmon calcitonin )

产品货号. M22788 CAS No. ——

Calcitonin（salmon） Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥2011 有现货
10MG ￥3358 有现货
25MG ￥4099 有现货
50MG 获取报价 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Calcitonin（salmon） Acetate(47931-85-1(free base))
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    Calcitonin（salmon） Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period.
  • 产品描述
    Calcitonin（salmon） Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period. At the end of the study period, oral Calcitonin salmon treatment by dose decreases diabetic hyperglycaemia by ~9 mM and reduces HbA1c levels by 1.7%. Furthermore, a pronounced reduction in glucose excursions is dose-dependently observed for oral Calcitonin salmon treatment during oral glucose tolerance test. In addition, oral Calcitonin salmon treatment sustains hyperinsulinaemia and attenuates hyperglucagonaemia and hypersecretion of total glucagon-like peptide-1 predominantly in the basal state. Lastly, oral Calcitonin salmon treatment dose-dependently improves pancreatic beta-cell function and beta-cell area at study end.
  • 同义词
    Salmon calcitonin
  • 通路
    GPCR/G Protein
  • 靶点
    CGRP Receptor
  • 受体
    calcitonin receptor;amylin
  • 研究领域
    Others
  • 适应症
    Forearm Fracture

化学信息

  • CAS Number
    ——
  • 分子量
    3431.85
  • 分子式
    C145H240N44O48S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    NC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cncn2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O.CC(=O)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Feigh M, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. Br J Pharmacol. 2012 Sep;167(1):151-63.
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    Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

  • PHM 27 (human)

    Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

  • Calcitonin（salmon） A...

    Calcitonin（salmon） Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period.

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